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التصنيف: antineoplastic agent.cyclin-dependent kinase inhibitor
المادة الفعالة: palbociclib

Palbociclib is an oral selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6), which regulate progression from the G1 to S phase of the cell cycle.
By blocking CDK4/6 activity, it prevents phosphorylation of the retinoblastoma (Rb) protein, leading to cell cycle arrest in hormone receptor–positive breast cancer cells.
It is primarily used in combination with endocrine therapy for HR-positive, HER2-negative advanced or metastatic breast cancer.
Common pharmacologic adverse effects include neutropenia, leukopenia, fatigue, and increased risk of infections.